About Ezetimibe: Ezetimibe is a lipid lowering drug, i.e. it lowers the levels of serum cholesterol. Ezetimibe interferes with the absorption of cholesterol and other sterols from the intestine. It also prevents the re-absorption and entero-hepatic circulation of biliary fats and cholesterol. This leads to a lowering of serum cholesterol levels in the blood, especially that of LDL-cholesterol, also known as 'bad' cholesterol. The lipid lowering action of Ezetimibe alone is weak. Hence it is commonly used in combination with an HMG-CoA reductase inhibitor, or a statin drug such as Atorvastatin or Simvastatin. With this combination also, the major action of Ezetimibe is in the reduction of LDL-cholesterol.
How Ezetimibe Works: Ezetimibe is a drug that reduces blood cholesterol levels. It inhibits the absorption of cholesterol and other sterols from the intestine. Ezetimibe interferes with the action of a transport protein NPC1C1 which acts as transporter for cholesterol. This interference reduces the absorption of cholesterol via this channel, including both dietary as well as biliary cholesterol. At first the total cholesterol level may increase due to compensatory synthesis by the liver. However the levels of LDL- cholesterol have been shown to eventually drop by approximately 15-20%. To prevent this increase from occurring, it is imperative that drugs like statins should be used in combination with Ezetimibe.
How To Take Ezetimibe: Buy Ezetimibe No Prescription is indicated when a patient has primary hypercholesterolemia or other conditions which are aggravated by high cholesterol levels such as cardiovascular disease, cerebrovascular disease and high blood pressure. However, Ezetimibe No Prescription is used only as adjunctive therapy along with dietary modification, change in lifestyle and daily exercise regimens. Medication is only indicated when these measures have not been completely adequate in reducing cholesterol levels to within desired limits. Ezetimibe is also used for familial hypercholesterolemia, but usually in combination with other lipid-lowering drugs such as Atorvastatin, Simvastatin or Fenofibrate. It is also indicated for use in a rare hereditary condition known as familial sitosterolemia where it is adjunctive therapy with dietary modification and assists in the control of high sitosterol and campesterol levels. Ezetimibe is available as oral tablets in the strength of 10 mg. The recommended starting dose of Buy Ezetimibe Without Prescription for the treatment of hypercholesterolemia is 10 mg taken as once daily dose, without relation to meals. When used with a statin or other lipid-lowering drug, Ezetimibe Without Prescription is taken as a single daily dose of 10 mg, preferably taken as the same time as the statin or any other drug being used. If Buy Ezetimibe is to be administered with a bile acid sequestrant drug such as Cholestyramine or Colestipol, then it is to be taken either 2 hours prior to or 4 hours after taking the bile acid sequestrant medication. This is to prevent sequestering of Ezetimibe No Prescription in the intestine, preventing its absorption and decreasing its efficacy. The effect of Ezetimibe may take up to 2 weeks to manifest. If a dose is missed, it should either be taken as soon as possible; or if the next dose is due soon, then one dose may be omitted.
Precautions And Side Effects Of Ezetimibe: Ezetimibe should not be used in patients with lactose intolerance since formulations of the medicine may contain lactose. It is to be used in caution in patients with liver dysfunction if it is taken in combination with a statin. Ezetimibe is not recommended for children under the age of 12 years. It may have severe adverse effects like myopathy and rhabdomyolysis. These side effects must be watched for carefully. Frequently seen side effects of Buy Ezetimibe are abdominal pain, diarrhoea, nausea, flatulence, fatigue, headache and dizziness. More serious effects of Ezetimibe Without Prescription are liver dysfunction, myalgias, myopathy, rhabdomyolysis, thrombocytopaenia, pancreatitis and increased propensity for gallstones.